A movement to promote and conduct research on the treatment and prevention of drug-resistant tuberculosis, with a commitment to address the substantial existing gaps in our knowledge and to help provide access to an effective cure and prophylaxis of drug-resistant tuberculosis throughout the world.


Nearly nine million people will develop tuberculosis (TB) in the world this year; at least 500,000 of these cases will have multidrug-resistant tuberculosis (MDR-TB). Some will receive treatment. However, we know little about the best ways of treating drug-resistant TB (DR-TB) and preventing tuberculosis in people who come in contact with DR-TB patients. Lacking a strong scientific basis in prescribing treatment regimens, existing TB treatments are often ineffective. TB control efforts require new evidence-based knowledge about optimal treatment regimens, prophylaxis, and, possibly, regimens involving new TB drugs, in order to address the growing health threats of MDR-TB and extensively drug-resistant (XDR) TB.

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NEXT Trial Approved by MCC in South Africa


The NEXT trial, an open-label RCT to evaluate a new treatment regimen for patients with MDR-TB, has been approved in South Africa by the Medicine Controls Council. The NEXT trial aims to evaluate the impact of a new injection-free six-to-nine month treatment regimen of linezolid, bedaquiline, levofloxacin, pyrazinamide and ethionamide/high dose isoniazid compared to the conventional empiric injection-based regimen of 21-24 months treatment. The secondary aim is to determine if other treatment-related outcomes including adverse events, adherence to treatment, culture conversion, and cure/completion are significantly different in the intervention and conventional arms. To read more about the NEXT trial, visit the ClinicalTrials.gov listing here.


Recent News and Announcements

Cycloserine price increase is rescinded

Cycloserine, an important drug used in regimens for the treatment of MDR-TB, increased in price last week from $500 to $10,800 for 30 capsules. The price increase came after the drug was acquired by Rodelis Therapeutics from The Chao Center. Following a swift response from providers, advocates, and policy makes, the drug was reacquired by the […]

2015 TAG and i-Base Pipeline Report released

Treatment Action Group and i-Base released the 2015 Pipeline Report for HIV, HCV, and TB, entitled “Drugs, Diagnostics, Vaccines, Preventive Technologies, Research Toward a Cure, and Immune-Based and Gene Therapies in Development.” The Pipeline Report summarizes progress and activities in HIV, Hepatitis C, and tuberculosis research. View the Pipeline Report here.

Nix-TB Trial for XDR-TB Launched

TB Alliance has announced the start of the Nix-TB trial, aimed at  testing all-oral drug regimen, that has the potential to shorten, simplify, and improve treatment for XDR-TB. Nix-TB will study a three-drug regimen of bedaquiline, pretonamid, and linezolid. To read more on the launch of the trial, visit the TB Alliance website here, and the […]

TB treatment added to WHO Essential Medicines List

The WHO Expert Committee on Selection and Use of Essential Medicines has recommended the inclusion of five TB medications in the WHO Model List of Essential Medicines. The recommended drugs include bedaquiline, delamanid, linezolid, rifapentine and terizidone. Rifapentine is indicated for the treatment of TB infection, while the other four medicines are included for the treatment of […]

TB activist Phumeza Tisile receives cochlear implant

Phumeza Tisile, an XDR-TB survivor and activist, lost her hearing due to side effects from drugs to treat XDR-TB. Last month, Phumeza received a cochlear implant and was able to hear for the first time in almost five years. Read her post here to hear more about this experience or visit her blog at the MSF […]

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