A massive new analysis of Mycobacterium tuberculosis isolates from around the world provides an "unparalleled view" of the mechanisms behind drug-resistant tuberculosis (TB). The analysis, described in two studies published last week in PLOS Biology, was conducted by scientists working with CRyPTIC (Comprehensive Resistance Prediction for Tuberculosis: an International Consortium), a large international effort employing whole-genome sequence (WGS) to create a comprehensive map of the genetic changes that are responsible for making TB drug-resistant. Read more here.
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