Frequency and type of microbiological monitoring of multidrug-resistant tuberculosis treatment

Kurbatova EV, Gammino VM, Bayona J, et al. IJTLD 2011; 15(11): 1553-5.

A retrospective analysis of three alternative monitoring strategies in a cohort of MDR-TB patients in Estonia, Latvia, Philippines, Russia and Peru (2000-2004), which illustrates that less frequent testing delays confirmation of bacteriological conversion. The delay prolongs intensive treatment, hospitalization, and respiratory isolation, increasing cost and toxicity. After conversion, less frequent testing could delay diagnosis of possible treatment failure.